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KMID : 0384119930130010001
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 1 p.1 ~ p.6
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LP(a): Possible Involvement in Thrombogenesis
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Abstract
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Lipoprotein(a) [Lp(a)] has been strongly linked with the pathogenesis of atherosclerosis and is now known as an independent risk factor for myocardial infarction. What distinguishes Lp(a)from other low-density lipoprotein particles is its content
of a
unique apoprotein, apo(a). The recently elucidated sequence of apo(a) indicates a remarkable homology with that of plasminogen, the zymogen of the primary thrombolytic enzyme, plasmin. If, by molecular mimicry, Lp(a) competes with plasminogen for
their
receptor, then thrombolysis will be inhibited and thrombosis promoted. In our study, the relationships between serum Lp(a) and other coagulatory and fibrinolytic indices were investigated in 39 subjects: 14 controls without coronary events and 25
patients with coronary heart disease. There wa a significant positive correlation of Lp(a) to plasminogen activator inhibitor [PAI](r=0.88, P=0.001). But Lp(a) concentration was not correlated with plasminogen, a-2antiplasmin, or tissue-type
plasminogen
activator [t-PA] (r<0.5). Also, no correlation was observed among plasminogen, a-2-antiplasmin, t-PA, and PAI. Thus, from the above, we could make an assumption that Lp(a) might be related to high levels of PAI.
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KEYWORD
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